the world's first personalised vaccine for melanoma skin cancer, hailed as a potential "game—changer" for treatment, is being tested on british patients. top us diplomat antony blinken is to meet with china's president xi in beijing shortly. i'm in front of their post office inquiry, where victims have gathered to hear a former senior post office executive questioned on what she knew and when she knew it. actress ashleyjudd calls the overturning of one of harvey weinstein�*s rape convictions an act of "institutional betrayal". there's no doubt that harvey weinstein is a serial sexual predator. it doesn't change the fact that he committed these crimes.

we are live at the unionjack club in london. ahead of the 80th anniversary of d—day, schoolchildren in london speak to veterans about what it was really like on the beaches of normandy. welcome to the programme. we start this hour with what experts are calling a potential "game—changer" in the treatment of skin cancer. the world's first personalised vaccine for melanoma — the deadliest form of skin cancer — has begun being tested in britain. some other countries, including australia, are also trying it on patients. the treatment, which uses the same mrna technology as some covid jabs, works by telling the body to hunt down cancer cells and prevent them from coming back. researchers say the jab also has the potential to stop lung, bladder and kidney cancers. more details from our health correspondent, sophie hutchinson: steve young, one of the first nhs patients to take part in the trial for what's hoped will be a game—changing treatment.

it's for melanoma — the deadliest of all the skin cancers — and it aims to help those at the highest risk of a recurrence. steve was given the experimental treatment at university college hospital in london. he had a melanoma removed from his scalp last summer. he told us the trial is his best chance of keeping cancer—free. i feel...ok. someone told me i've got survivor syndrome because i actually feel guilty — i feel guilty that i'm completely fine and yet i'm getting all this attention and i'm... you know, i get to have a scan and an mri every three months when i know that people are waiting such a long time. and i... i genuinely feel kind of awful about that. but... ijust really hope that what's happening with the trial and the results they get are going to be good news, and it's going to go on to do amazing things.

the personalised treatment works by identifying proteins unique to each person's cancer, and then uses the same technology which created some covid vaccines — called mrna — to prime the immune system to attack the cells. it's being used in combination with another cancer drug, and previous results suggest together it almost halved the risk of recurrence or death after three years. it's a very specific treatment, highly personalised to each individual's tumour, and it's a really exciting way of hopefully turning the patient's own immune system against their cancer. and it looks like it could be a really effective therapeutic approach. this trial will really prove that's the case or not. this is an international trial. uk doctors are hoping to recruit at least 70 patients across centres including london, manchester, edinburgh and leeds. sophie hutchinson, bbc news. let's find out more about the vaccine

from professor paul lorigan, who is overseeing the trial at the christie hospital in manchester. i'm amazed by this. just explain how the vaccine actually works and how is it individual to the person? it’s is it individualto the person? it's ve is it individual to the person? it�*s very exciting. we know that vaccines have transformed how we treat infectious diseases, save millions of lives and improve the quality of many others', and now it has been turned towards the treatment of cancer. it is, as you say, a personalised vaccine, so patients with melanoma, the most serious form of skin cancer, will have a melanoma removed. if they are at significant risk of recurrence, the melanoma that has been removed is analysed, the genetic material is broken down and we can identify the targets in

the melanoma cells that are particular to the melanoma cell and not to the normal cells, because the cancerous cells, of course, come from ourselves. having identified those, there is a clever algorithm which predicts which ones are most likely to stimulate the immune system and how it is going to react to those. and so it is instead turned into an mrna signal which is injected the same way you would have your flu vaccine or your covert vaccine. ,, ., your flu vaccine or your covert vaccine. , ., , ., , ., vaccine. so is it a single “ab or more than i vaccine. so is it a single “ab or more than one? i vaccine. so is it a single “ab or more than one? in * vaccine. so is it a single “ab or more than one? in this _ vaccine. so is it a single jab or more than one? in this trial, l vaccine. so is it a single jab or| more than one? in this trial, is civen more than one? in this trial, is given every _ more than one? in this trial, is given every time _ more than one? in this trial, is given every time we _ more than one? in this trial, is given every time we give - more than one? in this trial, is - given every time we give treatment for melanoma. what we need to work out with these is how best to give them and the frequency etc. before this, it is given for a period of a year while patients are treated. who year while patients are treated. who is caettin it year while patients are treated. who is getting it now and how long will trial last before it can go further?

there are currently ten centres in the uk and they are patients who are at high risk who have had a melanoma removed, but we know they are at significant risk of the cancer coming back. those patients are hopefully eligible for the trial. i think we will get a signal an answer within a few years rather than months. ~ . , ., ,., ., months. what is the global potential for this if it is _ months. what is the global potential for this if it is successful? _ months. what is the global potential for this if it is successful? for - for this if it is successful? for melanoma. — for this if it is successful? for melanoma, there _ for this if it is successful? for melanoma, there is - for this if it is successful? igrr' melanoma, there is huge potential. but the real potential here of course is expanding this into other cancers, because it's not a technology that just works with one cancer. if it works with melanoma, it could work across a number of different cancers, lung cancer, bowel and kidney cancer etc. so there is potential here for a transformative change in how we treat cancer. transformative change in how we treat cancer-— transformative change in how we treat cancer. ., , . ., treat cancer. how optimistic are you that that will — treat cancer. how optimistic are you

that that will happen? _ treat cancer. how optimistic are you that that will happen? i _ treat cancer. how optimistic are you that that will happen? i think - treat cancer. how optimistic are you that that will happen? i think you i that that will happen? i think you can sense that _ that that will happen? i think you can sense that there _ that that will happen? i think you can sense that there was - that that will happen? i think you can sense that there was a - that that will happen? i think you can sense that there was a lot. that that will happen? i think you can sense that there was a lot of| can sense that there was a lot of excitement about this, and it is based on how the technology works but also, we have done a smaller study with 150 patients and there was a strong signal from that that it would work. 50 was a strong signal from that that it would work.— was a strong signal from that that it would work. so we are optimistic. professor paul _ it would work. so we are optimistic. professor paul lorigan, _ it would work. so we are optimistic. professor paul lorigan, i'm - it would work. so we are optimistic. professor paul lorigan, i'm sure - professor paul lorigan, i'm sure everyone watching has their fingers crossed that that will be success. thank you forjoining us. to china next. in the past few moments, state media in china have said that america's top diplomat antony blinken has met the chinese president. mr blinken has already held talks in beijing with the foreign minister wang yi. mr wang said the us—china relationship had begun to stabilise in recent months, but negative factors were increasing. he said the choice was between international cooperation or rivalry and confrontation that

could even slide into conflict. mr blinken said it was important to discuss differences to avoid miscalculations. let's speak to our china correspondent stephen mcdonell, who's in beijing for us. so mr blinken had that meeting with the president?— so mr blinken had that meeting with the president? yeah, and you can see how important— the president? yeah, and you can see how important this _ the president? yeah, and you can see how important this visit _ the president? yeah, and you can see how important this visit is _ the president? yeah, and you can see how important this visit is that - the president? yeah, and you can see how important this visit is that the - how important this visit is that the us secretary of state has gone to the great hall of the people and met china's top leader to discuss the differences these two superpowers have. earlier, there words we got from both antony blinken and wang yi were very strong from both sides, making it pretty clear that they have these differences with one another. but many analysts would say it is good that they are having it

out in the open, because the worst thing would be for these two countries to have some sort of misunderstanding, which in the words of wang yi could lead to a slide into conflict. what he means by that is an accidental war starting in the south china sea or in the taiwan strait or something like that. so on the one hand, it's good that china and the us are talking about areas where they can cooperate, but the fact that they are also having discussions about their differences is also crucial.— is also crucial. what are likely to be those areas _ is also crucial. what are likely to be those areas of _ is also crucial. what are likely to be those areas of difference - is also crucial. what are likely to be those areas of difference that have been discussed behind closed doors? ~ ,, ., ., ., , doors? well, the us delegation has romised doors? well, the us delegation has promised to — doors? well, the us delegation has promised to call— doors? well, the us delegation has promised to call on _ doors? well, the us delegation has promised to call on china _ doors? well, the us delegation has promised to call on china to - doors? well, the us delegation has promised to call on china to stop i promised to call on china to stop supporting russia in its invasion of ukraine, and the chinese side has said that it will be telling antony

blinken to stop militarily supporting thai one, which it sees as a rogue province of china —— taiwan. those are the key points they want to criticise the other four, and they are all to do with military matters and their potential for greater conflict, so it is serious stuff.— for greater conflict, so it is serious stuff. ~' . . ., ., serious stuff. ukraine and taiwan were mentioned, _ serious stuff. ukraine and taiwan were mentioned, but _ serious stuff. ukraine and taiwan were mentioned, but they - serious stuff. ukraine and taiwan were mentioned, but they do - serious stuff. ukraine and taiwan| were mentioned, but they do also have economic differences, but need to cooperate economically because they are the two biggest economies in the world. they are the two biggest economies in the world-— in the world. they are completely interlocked. _ in the world. they are completely interlocked, and _ in the world. they are completely interlocked, and everybody - in the world. they are completely interlocked, and everybody else l in the world. they are completely| interlocked, and everybody else in the world also needs us and china to find a way forward. i think we are probably not going to go back to the more open trade that they did have now that certain product lines and certain types of equipment are being blocked by both sides. anything that has a potential military

application, and that can stray into the likes of ai application, and that can stray into the likes of al or what have you. but even if they can draw lines in the sand and set up guardrails and decide, we are going to have tariffs on these items, at least it is known what those items are, so which areas can they free trade up? the not knowing is the problem. that's why, for example, us businesses say they are wondering how the relationship is going to go because they have to decide whether or not to think big money into expanding their operations, and they need certainty. this is why these talks on the economy are also important. stephen mcdonell in beijing, _ economy are also important. stephen mcdonell in beijing, thank— economy are also important. stephen mcdonell in beijing, thank you. - hollywood actress ashleyjudd says the overturning of disgraced movie mogul harvey weinstein's 2020 rape conviction is a "hard day for survivors". she was the first woman to go public with the allegations against weinstein. new york's highest court has ruled

that he didn't get a fair trial, although the 72—year—old remains in prison. he was separately convicted of rape in los angeles. the 2020 case was a landmark in the me too movement and many activists, complainants, and lawyers say the overturning of his conviction as a setback for abuse survivors. ashleyjudd called the overturning "an act of institutional betrayal". she's been speaking to my colleague caitriona perry, who asked whether she would like to see weinstein re—tried. you know, what's important to know is that a courtroom is not a safe environment for survivors of male sexual violence. they can be very traumatising spaces. you know, the most dangerous place in america for a woman is in her home. we know the men who assault and rape and murder us. and a lot ofjudges are still catching up to that reality. and juries don't necessarily know that information either.

we still think of rape as stranger rape, as someone who jumps us in an alley. and so a courtroom isn't necessarily, even if harvey were retried and convicted in the state of new york, the place where survivors are going to get their healing. and that's what we need. that's what we need. it may be a fair outcome if he were convicted in new york, and that would sure be a magic wand. but survivors need trauma informed help and for men to stop raping women. his lawyer said that everyone has the right to justice. he said even people who are very unpopular in our society, no—one is above the law, but no—one is below the law either, he said. and i agree with that. yes, of course i do. everyone deserves justice and i support due process. i had the opportunity to meet the great supreme courtjustice ruth bader ginsburg,

and we talked about due process, even for people who are accused of the most egregious sexual crimes. and actually, right now at the university of kentucky, where i did my undergraduate degree, a couple of our former student athletes experienced terrible institutional betrayal and have accused my university, of which i'm very proud, and which i love, of complicity and other betrayals. and we're going to go through due process there. and i love my university enough to hold it accountable. so i definitely support due process. and there's no doubt that harvey weinstein is a serial sexual predator. it doesn't change the fact that he committed these crimes. over 100 women came forward after i was the named source in the new york times investigation. and on that point, a separate 16—year sentence handed down in california is not affected. he will stay in prison. he won't be freed. does that bring you and other survivors any sense of comfort, any sense ofjustice or that healing that you're describing? you know, it's more complex

than that, because i don't think the carceral system in the united states does perpetrators of male sexual violence any favours either. you know, what i would love to have is a restorative justice conversation with harvey weinstein. you know, i think that it's stories, it's narrative that helps change hearts and minds. i'm not about punitive measures. i'm about community and safety and belonging and forgiveness. i forgave harvey weinstein a long time ago, and it was no favour to him. i did it for myself. and, you know, it's a whole other conversation in terms of the american carceral system. but harvey hasn't had a change of heart. he doesn't necessarily — his last words when he was convicted and he was walking out of the courtroom were, "so how does this happen in the united states?" you know, and what would be a more satisfying outcome is if men looked at their entitlement to female

bodies and thought, "that is a person of dignity, she is a person of worth, and i do not have the right to encroach on her bodily autonomy". that would be satisfying. around the world and across the uk, this is bbc news.

to the latest on the israel—gaza war. the us military has started building a floating pier off the coast of gaza that will be used to boost humanitarian aid deliveries. the pier will be used to transfer supplies from ships to smaller vessels. the pier is expected to be in operation by early next month. a british naval vessel — the rfa cardigan bay — is to become a floating dormitory for hundreds of american soldiers and sailors in the eastern mediterranean helping deliver aid to gaza. earlier, the un relief agency

for palestinians — unrwa — warned about disease outbreaks in gaza amid worsening weather conditions, a lack of sufficient water and waste disposal. let's get more on all of this — with our diplomatic correspondent james landale, who's injerusalem. it's taken the us quite a while to get the boats and ships to build the pontoon to gaza, but they are starting that process?- pontoon to gaza, but they are starting that process? yeah, these vessels that _ starting that process? yeah, these vessels that are _ starting that process? yeah, these vessels that are putting _ starting that process? yeah, these vessels that are putting together l vessels that are putting together this floating platform in the eastern mediterranean, they don't move fast. so they have taken a while to cross over the atlantic to get into position. but as you say, the americans say that platform is now in the process of being made. the aid will be delivered and sorted out in cyprus at a port there. it will be checked by israeli forces to make sure the only aid is getting on

the ships. the ships will then head, large ships, 200 nautical miles south. they were then docked at this large floating platform that is in the process of being built. the aid will then be taken of the ships onto this floating platform. it will then be put into trucks. the trucks will then drive on to smaller landing craft. some of these craft will take up craft. some of these craft will take up to 15 trucks. and the landing craft with an shuttle onto the shore and at the shore, there's going to be another floating platform, and at the shore, there's going to be anotherfloating platform, a floating causeway that is anchored in the sand and is attached to the shore. the landing craft will off—load the trucks onto the causeway. the trucks will drive up the causeway onto the beach. they will deliver the aid into a secure safe zone that is secured by the israeli army, and then the trucks will turn around and head back and repeat the process. {iii will turn around and head back and repeat the process.— repeat the process. of course, the humanitarian _ repeat the process. of course, the humanitarian aid _ repeat the process. of course, the humanitarian aid is _ repeat the process. of course, the humanitarian aid is very _ repeat the process. of course, the humanitarian aid is very much - repeat the process. of course, the i humanitarian aid is very much needed still, and there is also that focus

on rougher and any possible israeli action and when that might take place —— in rafah? action and when that might take place -- in rafah?— place -- in rafah? he's really cabinet met— place -- in rafah? he's really cabinet met yesterday - place -- in rafah? he's really cabinet met yesterday and - place -- in rafah? he's really i cabinet met yesterday and there place -- in rafah? he's really - cabinet met yesterday and there is no sign yet that they have made any decision. some israeli defence forces this morning are claiming that people are beginning to leave rafah to get out because they have heard reports that the military operation is imminent. the israeli army claimed that could be over 100,000 people leaving, with no way of confirming those reports. we know that a lot of discussion has been going on about this. the cabinet that was meeting yesterday was not just talking about the operation in rafah, it was also talking about the prospects for a ceasefire. so those talks are still going on. egyptian officials are reportedly here in israel at the moment for those discussions. yesterday, there was an open letter written by the leaders of 18 countries including the us and the uk, urging hamas to agree some

kind of deal. so that process of trying to put pressure on both sides to agree some kind of ceasefire deal is still going on was that as yet, it has yet to bear any fruit. in the meantime, preparations forsome it has yet to bear any fruit. in the meantime, preparations for some kind of military operation in rafah continue. but again, this is going to be a long process, not a one—off moment. to be a long process, not a one-off moment. , ., , ., ., to be a long process, not a one-off moment. g . , . ., g moment. james landale in jerusalem, thank ou. the bbc has learned that a baby who was rescued from her dying mother's womb following an israeli air strike in gaza has died. sabreen al sakani was delivered by caesearean section in a rafah hospital shortly after midnight last sunday. doctors resuscitated the baby, using a hand pump to push air into her lungs. she was then placed in an incubator, but she died on thursday. two men arrested in connection with the deaths of five migrants in the english channel on tuesday have been charged and are expected to appear in court later.

five people, including a seven—year—old girl, were killed in a crush on board a boat crossing the channel. the uk's national crime agency said yien both, a 22—year—old from south sudan, has been charged with assisting unlawful immigration and attempting to arrive in the uk without valid entry clearance. tajdeen adbulazinuma, a 22—year—old sudanese national, has been charged with attempting to arrive in the uk without valid entry clearance. a third man, a 18—year—old from sudan, has been bailed pending further enquiries. let's turn our attention now to the ongoing post office inquiry looking into what's been called one of the biggest miscarriages ofjustice in british legal history. it's day two of evidence from the former senior post office executive, angela van den bogerd. she dealt with many of the legal cases against branch managers that saw more than 900 prosecuted because of a faulty it system. yesterday, she said she was "truly sorry" for the "devastation caused". let's speak to our

correspondent azadeh moshiri, who's at the inquiry. to your point, angela van den bogerd handled complaints from sub—postmasters about the horizon it system personally. she was also involved in the failed mediation scheme in 2013 between the victims and the post office, so it's going to take more than a day for the inquiry to get to the bottom of what she knew and when she knew it. we had a lot of testy exchanges yesterday. we are planning on hearing more today. there were a lot of "i don't recall", "it didn't register with me", "i didn't understand the implications", so much so that the chief counsel became pretty exasperated. there was a moment when she said she wasn't involved in the various areas of questioning and he said, can you tell us what you did do? we are expecting more questions about her knowledge of the issue of remote access which is central to the

scandal, the idea that fujitsu employees were able to access branch accounts without sub—postmasters even knowing the information that sub—postmasters were denied during these investigations and the wrongful prosecution is. we are also likely to hear more details about those sub—postmasters' personal cases. the lawyers of the sub—postmasters will be asking questions today and when they have been asking questions, it has tended to be far less clinical and far more impassioned because they personally represent victims whose lives have been destroyed by this scandal. i want to bring someone in, one of the victims. chris, thank you for your time. you were one of the youngest sub—postmasters in this scandal. can you tell me what you made a angela van den bogerd's apology yesterday? we knew she would start with an apology— we knew she would start with an apology in — we knew she would start with an apology in the morning, but the fact that we _ apology in the morning, but the fact that we saw shearer had to write down _ that we saw shearer had to write down a _ that we saw shearer had to write down a two line apology on a piece of paper— down a two line apology on a piece of paper and

down a two line apology on a piece of paperand said down a two line apology on a piece of paper and said she wanted to assist _ of paper and said she wanted to assist the — of paper and said she wanted to assist the inquiry to get the answers— assist the inquiry to get the answers we want and then move on to say "i _ answers we want and then move on to say "i don't _ answers we want and then move on to say "i don't recall, i didn't understand, i wasn't involved", we understand, iwasn't involved", we didnt— understand, iwasn't involved", we didn't get— understand, i wasn't involved", we didn't get any answers that we were promised _ didn't get any answers that we were promised we would get.— didn't get any answers that we were promised we would get. chris, i have been seeing — promised we would get. chris, i have been seeing you _ promised we would get. chris, i have been seeing you day _ promised we would get. chris, i have been seeing you day after— promised we would get. chris, i have been seeing you day after day - promised we would get. chris, i have been seeing you day after day here i been seeing you day after day here at the inquiry. you have been through a lot. how does it feel to come and listen them answer these questions and feel at the end of it that you don't feel like you got answers? �* , , that you don't feel like you got answers? 2 , , ., 2 answers? it's very frustrating. it's aood that answers? it's very frustrating. it's good that they — answers? it's very frustrating. it's good that they are _ answers? it's very frustrating. it's good that they are being - answers? it's very frustrating. it's good that they are being put - answers? it's very frustrating. it's good that they are being put in i answers? it's very frustrating. it's| good that they are being put in the hot seat _ good that they are being put in the hot seat to— good that they are being put in the hot seat to answer questions. we have _ hot seat to answer questions. we have seen— hot seat to answer questions. we have seen executives from the post office _ have seen executives from the post office and _ have seen executives from the post office and other organisations in the limelight to give their side of the limelight to give their side of the story, — the limelight to give their side of the story, but we are not hearing what _ the story, but we are not hearing what we — the story, but we are not hearing what we need to hear, which is the truth _ what we need to hear, which is the truth that — what we need to hear, which is the truth. that was all we asked for. thank— truth. that was all we asked for. thank you — truth. that was all we asked for. thank you. the post office has said it is deeply sorry for the impact on victims. angela van den bogerd has

said that she is cooperating with the inquiry. we are going to see more of this on this second day of her testimony.— more of this on this second day of her testimon . ~ . ~.,, ., ,, her testimony. azadeh moshiri, thank ou. hello. there was another chilly start for many of us, a touch of frost here and there. we have been shivering for days, we would like something warmer. we have to wait until the middle of next week before the temperatures recover. but for today, we are forecasting sunshine and showers and yes, it's going to be on the cold side. here is the forecast for friday. i weather front close to the uk spells out cloud and rain for cornwall, devon, close to the uk spells out cloud and rainfor cornwall, devon, somerset perhaps along the southern counties too. i suspect some damp weather for wales and generally cloudy. north of that, it's a day of sunny spells and scattered clouds and occasional showers across northern england, but

particularly across northern and eastern scotland. through this evening, if anything, the rain could turn heavierfor a time in the evening, if anything, the rain could turn heavier for a time in the south of the uk. certainly aligning along the m4, of the uk. certainly aligning along the ma, so a soggy picture through this evening overnight. north of that, with the clear skies, you can see a touch of frost for northern england, northern ireland and parts of scotland, around —2 in newcastle, so a really nippy start, but a sunny start across the north east of england. lake district also has some time first thing. but then that weather front crosses into the midlands and east anglia. the south coast brightens up a bit through the morning and into the afternoon, but there is another area of rain heading towards the south. temperature is recovering because the weather is also coming in from the weather is also coming in from the south. so a warmer direction, not that you are going to particularly feel the benefit because on sunday, is looking overcast with outbreaks of rain, widespread rain across much of

england. in scotland and northern ireland, your best bet for sunshine is here, but eventually, that rain will clear away into the north sea, leaving a legacy of cloud and dampness. temperatures typically into double figures with that weather coming in from the south. is it going to warm up? yes, it is. if we look at the atmosphere, the air mass here, the air is coming from the south—east, slightly warmer air, so that means temperatures will steadily climb. we are talking about the middle to high teens, so a gentle climb in the south, mid—teens in the north and the weather will remain a mixed bag. but i.

this is bbc news, the headlines... the world's first personalised vaccine for melanoma skin cancer, hailed as a potential "gamechanger" for treatment, is being tested on british patients. top us diplomat antony blinken is to meet with china's president xi in beijing shortly. actress ashleyjudd calls the overturning of one of harvey weinstein's rape convictions an act of "institutional betrayal". there is no doubt that harvey weinstein is a serial sexual predator. ...she she was involved in the felled mediation _ she was involved in the felled mediation scheme _ she was involved in the felled mediation scheme between i she was involved in the felled mediation scheme between the l she was involved in the felled i mediation scheme between the post office in 2015 so are likely to hear more personal cases about how she handled them. we are likely to hear more exchanges yesterday and we had a lot of i don't recall is. they didn't register with me, i didn't

understand the implications, so much